CTDP1 — CTD phosphatase subunit 1
CTDP1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTDP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | cAMP Lipid Signaling Immune regulation | ABL1, AKIRIN2, B9D2, CEMIP2, CHPT1, DKK3, GGA2, GSTM3 +15 more | |
| Mucosal-associated invariant T cell | Hypoxia-ER Stress Stress | ANKHD1, ARID1A, ARID4B, ATXN7, CEMIP2, CPD, EIF2AK3, ELF1 +5 more | |
| Natural Killer cells | Circadian Apoptotic Priming Stress | BBC3, CORO7, EML4, LDB2, NR1D2, OFD1, RNF125, SERPINE2 +1 more | View in SCUBA |
About the gene
| Synonyms | FCP1 |
|---|---|
| Chromosome | 18: 79679803-79754503 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M- phase-promoting factor (MPF)/CDK1 inactivation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.