CHPT1 — Choline phosphotransferase 1
CHPT1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHPT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Adhesion/Migration migration & adhesion | ADAM28, ADAMTS6, ARHGAP24, ARHGAP5, CLMN, CMTR2, FCMR, JAM3 +11 more | View in SCUBA |
| Enterocytes | Apicobasal polarity Migration & adhesion | ANK3, BRINP3, FOXP1, MCTP2, NEO1, PARD3B, VAV3 | View in SCUBA |
| Gamma-delta T cells | cAMP Lipid Signaling Immune regulation | ABL1, AKIRIN2, B9D2, CEMIP2, CTDP1, DKK3, GGA2, GSTM3 +15 more | |
| Hematopoietic progenitor cells | ER Protein Folding Housekeeping | ASRGL1, CALR, CD63, EMP3, GLUL, HSPA5, IDH2, MLEC +13 more | |
| Natural Killer cells | NK/ILC Differentiation Differentiation | ARHGAP9, CHKA, PIM2, PITPNC1, PPP1R16B, STAM, ZBTB16 | View in SCUBA |
About the gene
| Synonyms | CPT1 |
|---|---|
| Chromosome | 12: 101696947-101744140 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Function
Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and maintenance of vesicular membranes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.