cAMP Lipid Signaling
Gene co-expression module in Gamma-delta T cells
| Category | Immune regulation |
|---|---|
| Genes | 24 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 24 genes have a known function matching the annotation |
Why this annotation
PITPNC1 (phosphatidylinositol transfer, lipid signaling), PDE4A (cAMP phosphodiesterase, immune suppression), MAPKAPK2 (MK2, stress-activated MAPK substrate), RAPGEF2 (Rap1 GEF, integrin/adhesion), DKK3 (Wnt inhibitor), TLE3 (Groucho transcriptional corepressor), CHPT1 (lipid/choline phosphotransferase), PER2 (circadian clock gene), STX11 (SNARE protein, lymphocyte degranulation), and PABPC4 (mRNA stability). The module reflects a mixed program of intracellular lipid/cAMP signaling and post-transcriptional regulation. PDE4A-driven cAMP modulation is a known immune suppression axis in T cells.
Genes
ABL1, AKIRIN2, B9D2, CEMIP2, CHPT1, CTDP1, DKK3, GGA2, GSTM3, MAPKAPK2, MVB12B, PABPC4, PDE4A, PER2, PITPNC1, POLR1F, PPP1R16B, RAPGEF2, SPAG1, STX11, TLE3, UBE2J1, ZDBF2, ZNF746
Most correlated modules
- Chromatin Epigenetic Regulation · correlation 0.88
- TCR Threshold Regulation · correlation 0.87
- TCR Inhibitory Signaling · correlation 0.86
- Ubiquitin-p53 Regulation · correlation 0.83
- NF-κB Activation · correlation 0.81
- Autophagy Stress Response · correlation 0.80
- ER Stress Response · correlation 0.77
- IFN-gamma Receptor Signaling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.