TOMM40 — Translocase of outer mitochondrial membrane 40
TOMM40 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TOMM40's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | DNA Repair Housekeeping Housekeeping | ACBD6, CD320, DDX10, DUS1L, EEF1D, EIF3G, FAAP20, FARSA +15 more | View in SCUBA |
About the gene
| Synonyms | C19orf1, D19S1177E, PER-EC1, PEREC1, TOM40 |
|---|---|
| Chromosome | 19: 44890569-44903689 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Porin |
| Biological process | Ion transport, Protein transport, Transport |
Function
Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.