TRPC6 — Transient receptor potential cation channel subfamily C member 6
TRPC6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRPC6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Pericyte-like Fibroblast Migration & adhesion | CDK6, CHL1, DSEL, EHD2, ENTPD1, HEPH, ITGB3, NID1 +7 more | View in SCUBA |
About the gene
| Synonyms | FSGS2, TRP6 |
|---|---|
| Chromosome | 11: 101451564-101872562 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Calcium channel, Ion channel |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane- delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.