NID1 — Nidogen 1
NID1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NID1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actomyosin Contractility Cytoskeletal | BCAP29, CAPN2, GNB2, INPP5A, ITPRIPL2, LGALS1, LRRC8C, MPRIP +2 more | View in SCUBA |
| Fibroblasts | Pericyte-like Fibroblast Migration & adhesion | CDK6, CHL1, DSEL, EHD2, ENTPD1, HEPH, ITGB3, PLPP1 +7 more | View in SCUBA |
| Pericytes | Basement Membrane Assembly ECM production | F2R, FARP1, ITGB1, JAK1, LAMA4, LAMC1, LIMS1, PELO +1 more | View in SCUBA |
| Smooth muscle cells | Microfibril ECM Assembly ECM remodeling | ADAM28, FBN2, ITGA9, NEO1, PROM1, PSD3, SERPINE2, SPON1 +2 more | View in SCUBA |
About the gene
| Synonyms | entactin, NID |
|---|---|
| Chromosome | 1: 235975830-236065109 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.