Pericyte-like Fibroblast
Gene co-expression module in Fibroblasts
| Category | Migration & adhesion |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include NID1 (nidogen, basement membrane glycoprotein), ITGB3 (integrin beta-3, adhesion), CHL1 (cell adhesion molecule), DSEL (dermatan sulfate epimerase, ECM), ENTPD1 (ectonucleotidase), PTK7 (receptor tyrosine kinase involved in Wnt/PCP), EHD2 (endocytic recycling), and TRPC6 (calcium channel). The module reflects a fibroblast subpopulation with strong ECM/basement membrane and cell adhesion identity, consistent with a pericyte-like or subepithelial fibroblast. Mild inflammation downregulation supports a homeostatic identity.
Genes
CDK6, CHL1, DSEL, EHD2, ENTPD1, HEPH, ITGB3, NID1, PLPP1, PTGFRN, PTK7, RAP2A, TRPC6, UBE2E3, VAT1L, ZNF536
Most correlated modules
- Wnt-Niche Fibroblast · correlation 0.71
- WNT4+ Stromal Fibroblast · correlation 0.71
- Homeostatic Fibroblast Identity · correlation 0.68
- CCL11 Secretory Fibroblast · correlation 0.64
- BMP-ECM Fibroblast · correlation 0.63
- Stromal Niche Signaling · correlation 0.62
- TGF-beta Fibroblast Niche · correlation 0.59
- Interferon Response · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.