HEPH — Hephaestin
HEPH belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HEPH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Apical junction complex Migration & adhesion | ARHGAP32, KDM6A, KIAA1671, MYH14, NIPBL, PLEKHA7, POF1B, RBBP8 +3 more | View in SCUBA |
| Fibroblasts | Pericyte-like Fibroblast Migration & adhesion | CDK6, CHL1, DSEL, EHD2, ENTPD1, ITGB3, NID1, PLPP1 +7 more | View in SCUBA |
| Smooth muscle cells | Mesenchymal Adhesion Program Migration & adhesion | ANTXR1, BAG2, CDH11, COL12A1, CTSB, FHL3, FSTL3, PIM1 +6 more | View in SCUBA |
About the gene
| Synonyms | CPL, KIAA0698 |
|---|---|
| Chromosome | X: 66162671-66268867 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins, Transporters |
| Molecular function | Oxidoreductase |
| Biological process | Ion transport, Iron transport, Transport |
Function
Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form. Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body. By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.