CHL1 — Cell adhesion molecule L1 like
CHL1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Pericyte-like Fibroblast Migration & adhesion | CDK6, DSEL, EHD2, ENTPD1, HEPH, ITGB3, NID1, PLPP1 +7 more | View in SCUBA |
| Glial cells | Basement Membrane Adhesion ECM remodeling | ANTXR2, C2orf88, DMD, GPC1, ITGAV, PRIMA1, TMEM123 | View in SCUBA |
| Smooth muscle cells | Neural Adhesion Program Development | CNTN4, DSEL, EMID1, F3, IGFBP3, MATN2, SSC5D, STMN2 +1 more | View in SCUBA |
About the gene
| Synonyms | CALL, FLJ44930, L1CAM2, MGC132578 |
|---|---|
| Chromosome | 3: 196763-409417 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Cell adhesion, Differentiation, Neurogenesis |
Function
Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.