ENTPD1 — Ectonucleoside triphosphate diphosphohydrolase 1
ENTPD1 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENTPD1's module in each cell type
About the gene
| Synonyms | ATPDase, CD39, NTPDase-1, SPG64 |
|---|---|
| Chromosome | 10: 95711779-95877266 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Hydrolase |
Function
Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.