VAMP4 — Vesicle associated membrane protein 4
VAMP4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VAMP4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CD4 Lineage Identity T cell development | ACAA1, AGPAT3, ASCC3, ATF2, KIFAP3, KXD1, NEK7, PARP4 +6 more | View in SCUBA |
| Macrophages | Monocyte Innate Signaling Innate immunity | ADAMTSL4, IRAK1, LILRB3, MMP24OS, MYO1G, PGAP6, PLIN3, SHKBP1 +2 more | View in SCUBA |
About the gene
| Chromosome | 1: 171700160-171742074 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.