VIPR2 — Vasoactive intestinal peptide receptor 2
VIPR2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VIPR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ASPN+ Submucosal Fibroblast ECM production | ASPN, BCHE, CLEC14A, COL6A5, DIO2, FNDC1, HMCN1, HMCN2 +5 more | View in SCUBA |
About the gene
| Synonyms | VPAC2, VPAC2R |
|---|---|
| Chromosome | 7: 159028175-159144867 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase- activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of potency PACAP38 = VIP > PACAP27. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May be coupled to phospholipase C.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.