Oxidative Phosphorylation
Gene co-expression module in CD19⁺ B cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 11 genes have a known function matching the annotation |
Why this annotation
Top genes mix OxPhos (COX4I1, COX7C, UQCRB, SLC25A6 ADP/ATP translocase) with translation machinery (BTF3, EIF3K, EIF3H, RPL4, RPLP0, RPL36AL) and HINT1. Hubs are split between cytochrome oxidase components and ribosomal/translation factors. Given the OxPhos hub dominance and neighbor M19/M41 context, classify as OxPhos with strong housekeeping mix.
Genes
BTF3, COX4I1, COX7C, EIF3H, EIF3K, HINT1, RPL36AL, RPL4, RPLP0, SLC25A6, UQCRB
Most correlated modules
- Oxidative Phosphorylation · correlation 0.93
- Actin Cytoskeleton · correlation 0.84
- Actin Cytoskeleton · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.