Actin Cytoskeleton
Gene co-expression module in CD19⁺ B cells
| Category | Cytoskeletal |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Mixed module: cytoskeletal/actin genes (COTL1, TMSB4X, RAC2, MYL12A, MYL12B, TPM3, SH3BGRL3, SERPINB1) dominate alongside ER/secretory (SEC11A) and a couple OxPhos genes (HIGD2A, NDUFB5). Hub genes are predominantly actin/cytoskeleton regulators relevant to leukocyte motility, consistent with neighbor M11. Strong coherence.
Genes
COTL1, GNAI2, HIGD2A, MOB1A, MPG, MYL12A, MYL12B, NDUFB5, PRR13, PTRHD1, RAC2, SEC11A, SERPINB1, SH3BGRL3, TMSB4X, TPM3, TRABD
Most correlated modules
- Actin Cytoskeleton · correlation 0.91
- Actin Cytoskeleton · correlation 0.91
- Oxidative Phosphorylation · correlation 0.86
- Oxidative Phosphorylation · correlation 0.77
- Immunoproteasome IFN · correlation 0.77
- Actin cytoskeleton remodeling · correlation 0.75
- B cell activation · correlation 0.73
- Cytoskeleton/motility · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.