Actin Cytoskeleton
Gene co-expression module in CD19⁺ B cells
| Category | Cytoskeletal |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
Mixed module: actin/cytoskeleton regulators (ARPC3, GMFG, ARHGDIB, CAPNS1, TBCA) overlap with the M11/M14 cytoskeletal neighborhood, plus housekeeping (OAZ1, SERF2), one OxPhos (ATP5MG), an interferon gene (IFI27L2), and a transcription factor (TAF10). The cytoskeletal/Rho-actin theme (ARPC3, GMFG actin modulating factor, ARHGDIB Rho GDI) links it to neighbors. Core coherence.
Genes
ARHGDIB, ARPC3, ATP5MG, CAPNS1, GMFG, IFI27L2, OAZ1, SERF2, TAF10, TBCA
Most correlated modules
- Actin Cytoskeleton · correlation 0.96
- Oxidative Phosphorylation · correlation 0.93
- Oxidative Phosphorylation · correlation 0.91
- Actin Cytoskeleton · correlation 0.91
- Oxidative Phosphorylation · correlation 0.91
- mRNA Splicing · correlation 0.87
- Oxidative Phosphorylation · correlation 0.84
- Actin cytoskeleton remodeling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.