Immediate early activation
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 27 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 27 genes have a known function matching the annotation |
Why this annotation
Contains immediate-early/activation genes NR4A2, ZNF331, AREG, YPEL5, SLC2A3 (GLUT3, metabolic activation) and the AP-1/NR4A family of TCR-responsive transcription factors. NR4A2 and AREG are markers of TCR activation and Treg/effector function. SLC2A3 reflects glucose uptake on activation. The module represents an early T-cell activation / immediate-early response program.
Genes
ALG13, AREG, BCAS2, C9orf72, CXCR4, FAM222A, HIP1R, NR4A2, PABPC1, PDP1, PGAP1, PHLDB3, PRMT9, RNF139, SBDS, SC5D, SELENOK, SLC2A3, SNAPC1, SYAP1, VPS37B, YPEL5, ZBTB10, ZNF10, ZNF165, ZNF184, ZNF331
Most correlated modules
- TCR signaling · correlation 0.75
- TCR early activation · correlation 0.72
- Naive T cell · correlation 0.70
- Hypoxia metabolic stress · correlation 0.70
- Naive T cell · correlation 0.70
- T cell quiescence · correlation 0.67
- Naive resting T cell · correlation 0.64
- Naive T quiescence · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.