NFAT activation
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 22 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes FKBP5 (glucocorticoid-responsive), ITM2A, IRF2BP2, TGIF1, NFATC1, ETV6, NFIA point to a TCR/NFAT-linked transcriptional and steroid-response program. NFATC1 and IRF2BP2 are transcriptional regulators downstream of TCR signaling; FKBP5 is a classic glucocorticoid target. The module reflects an activation/transcriptional regulation state, with NFAT signaling central.
Genes
AHI1, ASAP1, BCAT1, BICDL1, CPM, CYP7B1, ETV6, FAM107B, FKBP5, IGFBP4, INPP4B, IRF2BP2, ITM2A, ITPKB, MYO6, NFATC1, NFIA, NR3C1, PDE7B, PPP1CC, TGIF1, TMEM67
Most correlated modules
- CD200 immunoregulation · correlation 0.81
- Tfh program · correlation 0.79
- Tfh IL21 help · correlation 0.78
- Tfh CXCL13 program · correlation 0.72
- Naive resting T cell · correlation 0.58
- Integrin adhesion · correlation 0.58
- Proliferation/differentiation · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.