Resting memory T cell
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
Strong hub IL7R (CD127) plus ANXA1, MYADM, RBMS1 define a resting/memory CD4 T cell homeostasis program. IL7R and ANXA1 are classic markers of resting/memory T cells; CD300A is an inhibitory receptor; ANXA1 dampens inflammation. Negative delta_inflammation_UC and positive remission consistent with a quiescent homeostatic state lost in active disease. This module is a topological neighbor of M113 (quiescence) and shares a resting T cell theme.
Genes
ANXA1, CD300A, CDC14A, CYB561, DHRS3, DYNLT3, IL7R, MYADM, NECTIN3, PATJ, RBMS1, RNF157, SPART, TANC2
Most correlated modules
- TCR signaling · correlation 0.91
- Cytotoxic effector · correlation 0.85
- Cytokine signaling · correlation 0.84
- T cell quiescence · correlation 0.81
- Ribosomal proteins · correlation 0.74
- Unfolded Protein Response · correlation 0.73
- NF-kB Feedback Response · correlation 0.70
- Cytotoxic Effector CD4 · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.