DNA damage response
Gene co-expression module in CD4⁺ T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Moderate coherence module with DNA-damage/chromatin genes as hubs: RNF168 (DNA damage ubiquitin signaling), CENPC (centromere), KMT5C (H4K20 methyltransferase), TRMT10C, DEAF1, SESN1 (sestrin stress). Mix of chromatin/DNA-repair and mito/stress genes with several weak/moderate memberships indicates a mixed program. The DNA-damage/chromatin maintenance theme (RNF168, CENPC, KMT5C) is most identifiable. Lower inflammation correlation than neighbors.
Genes
ATP2B1, CENPC, DEAF1, FBXO34, HAX1, HECTD1, KMT5C, MRPL50, NDUFA5, NOC2L, PPIG, RNF168, SESN1, TRMT10C, UBA2, ZMYM5
Most correlated modules
- IL6-STAT3 Signaling · correlation 0.77
- T cell Coinhibition · correlation 0.76
- Vesicle trafficking · correlation 0.72
- Cellular biosynthesis · correlation 0.68
- Membrane trafficking · correlation 0.65
- ER-Golgi Trafficking · correlation 0.57
- CD200 immunoregulation · correlation 0.52
- TCR signaling · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.