Proliferation/differentiation
Gene co-expression module in CD4⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 2 of 8 genes have a known function matching the annotation |
Why this annotation
Small, moderate-coherence module with CCND1 (cyclin D1, cell cycle/proliferation), KLF4, TLR5, DTX1 (Notch target/anergy), SUSD4. Mixed signals but CCND1 hub and KLF4 suggest a proliferation/differentiation state. DTX1 links to T cell anergy/regulation. Heterogeneous; low confidence.
Genes
AIG1, AKAP7, CCND1, DTX1, KLF4, SUSD4, TLR5, ZNF827
Most correlated modules
- CD200 immunoregulation · correlation 0.59
- T cell signaling · correlation 0.55
- Naive T cell · correlation 0.53
- Naive resting T cell · correlation 0.52
- NFAT activation · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.