Growth Arrest Senescence
Gene co-expression module in Colorectal carcinoma
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
CDKN1A (p21/CIP1, canonical cell cycle inhibitor and senescence marker), RHOF (Rho-F/filopodia-inducing GTPase), TSPAN1 (tetraspanin-1, promotes invasion in CRC), QSOX1 (quiescin sulfhydryl oxidase, secreted to promote ECM crosslinking and invasion), SLC16A3 (MCT4, lactate exporter — Warburg effect), ISG20 (interferon-stimulated exonuclease), MALL (mal/T-lymphocyte maturation-associated), CDA (cytidine deaminase, nucleotide metabolism). The combination of CDKN1A-driven growth arrest with Warburg metabolism (SLC16A3) and invasion elements (TSPAN1, QSOX1, RHOF) suggests a stress-induced growth-arrested but metabolically active CRC state reminiscent of therapy-induced senescence or quiescence.
Genes
Most correlated modules
- ECM Invasion Program · correlation 0.91
- Clathrin-mediated Endocytosis · correlation 0.87
- Tight Junction Integrity · correlation 0.85
- Complement Immune Evasion · correlation 0.83
- Epithelial Cell Adhesion · correlation 0.78
- NF-κB Chemokine Response · correlation 0.77
- STAT3 Oncogenic Signaling · correlation 0.77
- Epithelial Junctional Cytoskeleton · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.