Clathrin-mediated Endocytosis
Gene co-expression module in Colorectal carcinoma
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes include CLTB (clathrin light chain B, endocytosis/vesicular trafficking), RHOC (Rho GTPase regulating actin cytoskeleton and vesicle trafficking), CYSTM1 (cysteine-rich transmembrane module), FHL2 (four-and-a-half LIM domain protein, cytoskeletal signaling adaptor), SH3BGRL3 (SH3 domain binding glutamate-rich protein, cytoskeletal regulation), TMEM54 (transmembrane protein involved in membrane integrity). CLTB and RHOC anchor this module to clathrin-mediated endocytosis and cytoskeletal organization. FHL2 and SH3BGRL3 reinforce cytoskeletal/adhesion signaling. PDZK1IP1 (MAP17) is expressed in epithelial cells. Uniform expression across subsets. The module reflects general epithelial endocytic and cytoskeletal maintenance rather than a specific disease program. Closest to vesicular trafficking given CLTB centrality and RHOC role in vesicle budding.
Genes
Most correlated modules
- Tight Junction Integrity · correlation 0.91
- Growth Arrest Senescence · correlation 0.87
- Epithelial S100/Keratin · correlation 0.84
- Endosomal Vesicle Recycling · correlation 0.80
- Metabolic Stress Response · correlation 0.76
- ECM Invasion Program · correlation 0.73
- Endolysosomal Autophagy · correlation 0.73
- Epithelial Cell Adhesion · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.