Metaphase-Anaphase Transition
Gene co-expression module in Colorectal carcinoma
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Core-coherent, all genes canonical mitotic regulators. CDC20 activates APC/C to degrade securin and cyclin B. CCNB1/CCNB2 are B-type cyclins whose destruction marks mitotic exit. CDKN3 (KAP) dephosphorylates CDK2. BIRC5 (survivin) is an chromosomal passenger complex member required for chromosome alignment and cytokinesis. PTTG1 (securin) inhibits separase until CDC20-APC/C degrades it. CENPA is the centromere-specific histone H3 variant. CKS2 is a CDK regulatory subunit. TROAP (tastin) stabilises astral microtubules. Together these define the APC/C-securin-cyclin destruction cascade of metaphase-to-anaphase transition.
Genes
Most correlated modules
- G2/M Entry & PLK1 · correlation 0.95
- Kinetochore Assembly · correlation 0.94
- G2/M Transition · correlation 0.90
- Late Mitosis/Cytokinesis · correlation 0.89
- Mitotic Spindle · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.