G2/M Transition
Gene co-expression module in Colorectal carcinoma
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes BUB3 (spindle assembly checkpoint), SKA2 (kinetochore-spindle attachment), TUBA1C/TUBB4B (tubulins), UBE2S (APC/C-dependent ubiquitination in mitotic exit), HMGB1/HMGB3 (chromatin remodeling in proliferating cells), DDX39A (RNA helicase active in S/G2), SRSF3/SNRPC (splicing factors co-regulated with cell cycle), ANP32E (histone chaperone). This is a mixed but coherent module spanning late S/G2/M-phase programs — chromosome segregation machinery, tubulin dynamics, and RNA processing coupled to cell division. Neighbor modules M42, M19, M28, M37, M31, M52 are all clearly cell-cycle modules, reinforcing this classification. The mixture of spindle checkpoint (BUB3, SKA2), tubulins, and chromatin/RNA factors places this in a G2/M transition context.
Genes
Most correlated modules
- Kinetochore Assembly · correlation 0.95
- Mitotic Spindle · correlation 0.91
- Metaphase-Anaphase Transition · correlation 0.90
- Nucleotide Biosynthesis · correlation 0.87
- Pre-mRNA Splicing · correlation 0.86
- Chromatin & DNA Repair · correlation 0.86
- G2/M Entry & PLK1 · correlation 0.86
- Late Mitosis/Cytokinesis · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.