G2/M Entry & PLK1
Gene co-expression module in Colorectal carcinoma
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
All eight genes are core-coherent and expressed uniformly. NEK2 phosphorylates centrosomal linker proteins to initiate centrosome separation in G2. PLK1 (Polo-like kinase 1) is the master regulator of mitotic entry and spindle assembly. CCNA2 (cyclin A2) drives S/G2 CDK2 and CDK1 activity. HMMR (RHAMM) organises the spindle pole. DEPDC1 promotes G2/M transition. KPNA2 (importin α1) mediates nuclear import of mitotic regulators. NUF2 is a kinetochore Ndc80-complex component. DLGAP5 (HURP) stabilises kinetochore-microtubule attachments. This module is specifically centred on G2/M entry and centrosome maturation, driven by PLK1 and NEK2.
Genes
Most correlated modules
- Late Mitosis/Cytokinesis · correlation 0.95
- Metaphase-Anaphase Transition · correlation 0.95
- Kinetochore Assembly · correlation 0.89
- G2/M Transition · correlation 0.86
- Mitotic Spindle · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.