ER Lumenal Homeostasis
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
CNPY2 (canopy 2, ER luminal chaperone assisting MHC-I and TLR folding), ERP29 (ER protein 29, luminal chaperone facilitating protein secretion), TMEM205 (ER/Golgi membrane protein), PLPP2 (phospholipid phosphatase 2, ER membrane lipid metabolism), TMEM147 (ER membrane protein involved in cytochrome P450 maturation), and GPAA1 (GPI anchor transamidase, ER-localized) collectively define ER lumenal and membrane functions related to protein folding and lipid metabolism. ISCU (iron-sulfur cluster assembly) and MGST2 (microsomal glutathione S-transferase, ER membrane) are peripheral. The neighborhood context (surrounded by ER-Golgi and translocon modules) supports classification as an ER membrane/lumenal homeostasis program.
Genes
Most correlated modules
- ER Signal Peptide Processing · correlation 0.91
- ER-Golgi Trafficking · correlation 0.81
- Mitochondrial Import & Complex I · correlation 0.79
- Metabolic Enzyme Housekeeping · correlation 0.76
- ER-Golgi Membrane Maintenance · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.