ER-Golgi Membrane Maintenance
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
SNRPA1 encodes a U2 snRNP component (mRNA splicing), POLR2H is an RNA Pol II subunit (transcription), TXNL1 is thioredoxin-like (redox/protein quality control), SARAF regulates ER Ca²⁺ homeostasis, LEPROTL1 and TMEM167A are ER/Golgi transmembrane proteins, ASAH1 is a ceramide-metabolizing enzyme, and ODC1 drives polyamine biosynthesis. Moderate coherence and low expression with no clear dominant program; the closest unifying theme is ER/Golgi membrane housekeeping with splicing/transcription machinery co-expression, consistent with its neighbor modules M15 and M75.
Genes
Most correlated modules
- ER Protein Processing · correlation 0.89
- hnRNP RNA Processing · correlation 0.84
- ER-Golgi Trafficking · correlation 0.80
- Ubiquitin-Proteasome System · correlation 0.80
- Endosomal Vesicle Recycling · correlation 0.79
- RNA-protein Transport · correlation 0.79
- Actin-Vesicle Coupling · correlation 0.77
- ER Lumenal Homeostasis · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.