ER Signal Peptide Processing
Gene co-expression module in Colorectal carcinoma
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
SSR2 (signal sequence receptor beta, part of the translocon-associated protein/TRAP complex), SEC11C (signal peptidase complex subunit), VKORC1 (ER membrane vitamin K epoxide reductase), KRTCAP2 (keratinocyte-associated protein 2, ER membrane), TMBIM4 (ER-localized anti-apoptotic protein regulating calcium), C1orf43 (ER-associated), and JTB (ER-Golgi membrane protein) all localize to the ER membrane and participate in protein translocation and processing. LAMTOR2 (lysosomal adaptor for mTORC1) and ATP6V0B (V-ATPase) extend into the endolysosomal axis. This is a strongly coherent ER signal peptide processing and translocation module, neighboring the ER-Golgi (M5) and ER processing (M39) modules.
Genes
Most correlated modules
- ER Lumenal Homeostasis · correlation 0.91
- ER Protein Processing · correlation 0.84
- Endolysosomal Autophagy · correlation 0.83
- Actin-Vesicle Coupling · correlation 0.82
- Mitochondrial Import & Complex I · correlation 0.82
- ER-Golgi Trafficking · correlation 0.81
- ER Protein Processing · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.