ER-Golgi Trafficking
Gene co-expression module in Colorectal carcinoma
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes LMAN2 (ER-Golgi lectin receptor for glycoprotein cargo), RER1 (ER retrieval from Golgi), REEP5 (ER tubule shaping), TMED9 (p24 family COPI vesicle coat), YIF1A (Golgi membrane protein), and MANF (ER luminal neurotrophic factor/UPR-related) all localize to the early secretory pathway. HEXB is lysosomal but participates in the downstream secretory route. The module is uniformly expressed, strongly coherent, and represents constitutive ER-to-Golgi anterograde and retrograde trafficking machinery.
Genes
Most correlated modules
- ER Protein Processing · correlation 0.91
- Actin Cytoskeleton Regulation · correlation 0.87
- Endolysosomal Autophagy · correlation 0.84
- ER Protein Processing · correlation 0.82
- ER Signal Peptide Processing · correlation 0.81
- ER Lumenal Homeostasis · correlation 0.81
- Ubiquitin-Proteasome System · correlation 0.81
- ER-Golgi Membrane Maintenance · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.