Metabolic Enzyme Housekeeping
Gene co-expression module in Colorectal carcinoma
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
HINT2 is a mitochondrial histidine triad nucleotide-binding protein involved in fatty acid/metabolic regulation. AKR7A2 is an aldo-keto reductase mediating xenobiotic/aldehyde detoxification. GCHFR (GTP cyclohydrolase I feedback regulator) controls tetrahydrobiopterin synthesis, a cofactor in multiple metabolic reactions. NANS catalyzes sialic acid biosynthesis. ZDHHC12 palmitoylates membrane proteins. MZT2A/B are microtubule nucleation factors (gamma-TuRC). ARPC1B is an ARP2/3 complex member. The module is heterogeneous with moderate coherence, combining disparate metabolic enzymes. The unifying theme may be general metabolic housekeeping, though no single dominant pathway emerges cleanly.
Genes
Most correlated modules
- Oxidative Phosphorylation ETC · correlation 0.88
- Mitochondrial Ribosome · correlation 0.87
- Proteasome Ubiquitin Degradation · correlation 0.86
- ER-Golgi Trafficking · correlation 0.78
- ER Lumenal Homeostasis · correlation 0.76
- Aerobic Glycolysis Warburg · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.