DC Differentiation Migration
Gene co-expression module in Dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
The top hub genes include ITGA4 and ITGAL (gut-homing integrins critical for DC migration), RUNX1 (master transcription factor for DC development and differentiation), CDKN1B/p27 (marks post-mitotic differentiated state), CCDC88B (DC migration regulator), and epigenetic regulators SETD2 and MTF2/PCL2 that likely govern the differentiation program. NOD2 and CYBC1 add innate immune sensing context. The module is moderately coherent, reflecting a mixed but related program of DC differentiation coupled with migratory capacity in the gut.
Genes
Most correlated modules
- Proliferating DC Program · correlation 0.85
- mRNA Splicing · correlation 0.84
- Genome Maintenance · correlation 0.79
- Endosomal DC Program · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.