Proliferating DC Program
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Strongly enriched in prolif_DC (12.2x). SETX (senataxin, resolves R-loops at transcription-replication conflicts), UPF2 (nonsense-mediated mRNA decay), TRMT1 (tRNA modification), KPNA4 (importin-alpha, nuclear transport) suggest RNA surveillance and nuclear transport programs active in proliferating DCs. POU2F2 (Oct-2, DC/B-cell TF), NKRF (NF-κB repressor), NRARP (Notch/Wnt target), and MAP3K3 add transcriptional regulation. ICAM2 (DC adhesion/identity marker) and AMPD2 (purine metabolism) are consistent with DC identity maintenance. The module likely reflects transcriptional/RNA quality control programs specifically active in proliferating DCs.
Genes
Most correlated modules
- p53 Transcriptional Regulation · correlation 0.91
- Phagocytic Cytoskeletal · correlation 0.90
- Transcriptional Homeostasis · correlation 0.89
- Glucocorticoid Stress Response · correlation 0.87
- DC Differentiation Migration · correlation 0.85
- RNA Splicing Processing · correlation 0.84
- mRNA Splicing · correlation 0.82
- Immediate Early Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.