Endosomal DC Program
Gene co-expression module in Dendritic cells
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 34 genes have a known function matching the annotation |
Why this annotation
Hub gene WDFY2 is a FYVE-domain endosomal protein involved in endosomal sorting and cross-presentation in cDC1. HHEX is a transcription factor involved in DC development. TLE4 is a Groucho transcriptional repressor. ATG16L2 is an autophagy-related gene. SLA (Src-like adaptor) regulates immune receptor signaling. CNTRL (centriolin) and MIS18BP1 are centrosome/cell cycle genes enriched in prolif_DC. RIOK1 is a kinase involved in ribosome biogenesis. TNF is weakly expressed but cDC1-enriched. CPT1A is fatty acid oxidation. CD180 (RP105) is a TLR4 co-receptor. JADE1 is a chromatin regulator. The module is mixed: proliferating DC genes (CNTRL, MIS18BP1, RIOK1, JADE1) co-occur with endosomal/DC-identity genes (WDFY2, HHEX, SLA). WDFY2's role in endosomal trafficking and cross-presentation in cDC1 is notable. Given the neighbor context (M71 housekeeping, M142 cDC1 epigenetic), this module likely captures a cDC1-associated endosomal/developmental program mixed with proliferation-related genes.
Genes
Most correlated modules
- DC Proliferation Program · correlation 0.88
- RNA Processing Proliferation · correlation 0.85
- Telomere Maintenance · correlation 0.84
- cDC1 Epigenetic Regulation · correlation 0.80
- Genome Maintenance · correlation 0.79
- DC Differentiation Migration · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.