mRNA Splicing
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes FUS (RNA-binding protein, splicing/transcription), RBM39 (splicing factor), SF1 (splicing factor 1), NXF1 (nuclear RNA export factor), SUGP2 (splicing), DDX3X (RNA helicase), BCLAF1 (splicing/transcription), PNN (splicing regulator), SECISBP2 (selenoprotein mRNA binding) point strongly to RNA processing and splicing. YME1L1 is a mitochondrial protease but is a peripheral member. VMP1 is involved in autophagy/ER. RAD9A is DNA damage checkpoint. BRD2 is a bromodomain transcriptional regulator. The dominant program is mRNA splicing and nuclear RNA metabolism, broadly expressed (uniform) with moderate coherence. Neighbor modules M142 and M73 also contain splicing/chromatin genes, consistent with a shared housekeeping RNA-processing neighborhood.
Genes
Most correlated modules
- Glucocorticoid Stress Response · correlation 0.85
- p53 Transcriptional Regulation · correlation 0.85
- DC Differentiation Migration · correlation 0.84
- Proliferating DC Program · correlation 0.82
- Immediate Early Response · correlation 0.82
- Alternative Splicing · correlation 0.82
- Genome Maintenance · correlation 0.81
- RNA Splicing Processing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.