Genome Maintenance
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 35 genes have a known function matching the annotation |
Why this annotation
Hub genes: BOD1L1 (DNA damage response, replication fork protection), PNKP (polynucleotide kinase/phosphatase, DNA repair), CTBP1 (transcriptional co-repressor), SNRNP200 (spliceosome helicase), SON (splicing factor), NSD3 (histone methyltransferase), AGO3 (Argonaute, miRNA/RISC), HECTD1 (E3 ubiquitin ligase), ATRX (chromatin remodeler, DNA repair), CNOT1 (CCR4-NOT deadenylase complex), THOC2 (THO complex, mRNA export), SRRT (serrate RNA effector, miRNA processing), USP3/USP16 (deubiquitinases, histone H2A). The module combines DNA repair (BOD1L1, PNKP, ATRX, USP3, USP16), chromatin regulation (NSD3, CTBP1, ATRX), RNA processing (SNRNP200, SON, THOC2, CNOT1, AGO3, SRRT), and ubiquitin regulation. This is a broad chromatin/genome maintenance housekeeping program. Neighbor M71 is also RNA processing, supporting a shared housekeeping neighborhood.
Genes
Most correlated modules
- RNA Processing Proliferation · correlation 0.88
- Phagocytic Cytoskeletal · correlation 0.86
- Transcriptional Homeostasis · correlation 0.83
- Golgi-Lysosome Trafficking · correlation 0.83
- mRNA Splicing · correlation 0.81
- mDC Vesicular Trafficking · correlation 0.80
- DC Differentiation Migration · correlation 0.79
- Endosomal DC Program · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.