DNA Damage Response
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
This module has weak coherence and most hub genes have weak membership scores. POLE4 (DNA polymerase epsilon subunit), TP53 (tumor suppressor/cell cycle checkpoint), GPI (glycolytic enzyme), HSPA9 (mitochondrial chaperone), TBC1D15 (Rab7 GAP involved in mitophagy/vesicle trafficking), TRAPPC6A (TRAPP complex, vesicle tethering), ARMCX3 (mitochondria-associated), SMU1 (splicing), JDP2 (AP-1 transcription factor), TCEAL8 (transcription elongation). The module lacks a tight biological theme; it combines DNA repair/cell cycle (POLE4, TP53), metabolic (GPI, HSPA9), and vesicular (TBC1D15, TRAPPC6A) genes. PXK is mildly enriched in prolif_DC. The weak coherence and mixed membership suggest this is a poorly defined module possibly capturing a loose proliferation/stress-associated program. TP53 and POLE4 point toward a DNA damage/cell cycle checkpoint context. Given the neighbor M95 has proliferation-associated genes (GAS2L3, TTF1, GPATCH11 in prolif_DC), this module likely captures a peripheral proliferation-stress overlap.
Genes
Most correlated modules
- Myeloid Inhibitory Receptors · correlation 0.86
- Lysosomal Vesicular Trafficking · correlation 0.85
- Gut-Homing DC · correlation 0.85
- Endosomal Retromer Trafficking · correlation 0.84
- DNA Damage Repair · correlation 0.83
- DC Actin Migration · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.