Gut-Homing DC
Gene co-expression module in Dendritic cells
| Category | Migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
ITGB7 (α4β7 integrin, gut-homing receptor for MAdCAM-1) is a key gut-homing marker. SIGLEC10 (inhibitory sialic acid-binding receptor), HVCN1 (voltage-gated proton channel supporting phagosomal NADPH oxidase), LAMTOR4 (lysosomal adaptor for mTORC1 on late endosomes), and EVI2B (myeloid differentiation) suggest a gut-resident DC program with inhibitory and lysosomal features. NDRG2 (stress-responsive, expressed in tolerogenic contexts), GLIPR1 (immune modulator), and DUSP23 (phosphatase) add regulatory depth. Uniform expression with no significant inflammation response supports a homeostatic gut-resident DC identity. ITGB7 is the strongest gut-specific anchor.
Genes
Most correlated modules
- DC Proliferation Program · correlation 0.89
- DNA Damage Repair · correlation 0.89
- Tolerogenic DC State · correlation 0.88
- Focal Adhesion Remodeling · correlation 0.88
- Myeloid Inhibitory Receptors · correlation 0.88
- Lysosomal Vesicular Trafficking · correlation 0.87
- Myeloid DC Identity · correlation 0.85
- DNA Damage Response · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.