Lysosomal Vesicle Trafficking
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes: ATP1A1 (Na+/K+-ATPase alpha-1, ion homeostasis), G3BP2 (stress granule assembly, RNA binding), GM2A (GM2 ganglioside activator, lysosomal lipid degradation), DHX36 (RNA helicase, G-quadruplex resolution), LDLRAD4 (LDL receptor-related, TGF-beta signaling), CDV3 (carnitine deficiency-associated), RBM25 (splicing), ATP6V1H (V-ATPase subunit, lysosomal acidification), AUP1 (ER lipid droplet/ERAD), SEC62 (ER translocation), CDC37 (HSP90 co-chaperone), GSPT1 (translation termination), TRIP11 (GMAP-210, Golgi), NSMAF (neutral sphingomyelinase activation factor, ceramide signaling). The cDC1 enrichment and presence of ATP6V1H (lysosomal V-ATPase), GM2A (lysosomal), and NSMAF (sphingolipid/ceramide) alongside ER components (SEC62, AUP1) and Golgi (TRIP11) suggest a vesicular trafficking and lysosomal program relevant to antigen processing in cDC1. ATP1A1 maintains ion gradients important for endosomal function. The strong treatment response (delta_treatment = -0.191) is notable. This module fits vesicular/lysosomal trafficking in cDC1.
Genes
Most correlated modules
- cDC1 Epigenetic Regulation · correlation 0.83
- Unfolded Protein Response · correlation 0.78
- Golgi-Lysosome Trafficking · correlation 0.75
- ER Protein Processing · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.