Golgi-Lysosome Trafficking
Gene co-expression module in Dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
Weak coherence module enriched in prolif_DC (8.5x) and cDC1 (2.5x). GOPC (Golgi-associated PDZ protein, vesicle trafficking), COPA (COPI coat, Golgi-to-ER retrograde transport), ST3GAL2 (Golgi sialyltransferase), GGA2 (Golgi-to-lysosome adaptor for M6P receptors), PDE4DIP (AKAP at Golgi/centrosome), and IGF2R (mannose-6-phosphate receptor, lysosomal enzyme targeting) collectively define a Golgi-to-lysosome vesicular trafficking program. DYNLL2 (dynein light chain, vesicle transport) and KRTCAP2 (ER membrane) add endomembrane context. ZC3H12C (MCPIP3, RNA endonuclease, cDC1 enriched) and SIRT1 are peripheral members. The weak coherence reflects mixing of Golgi trafficking with unrelated genes, but the vesicular trafficking theme is the dominant signal.
Genes
Most correlated modules
- RNA Processing Proliferation · correlation 0.84
- Genome Maintenance · correlation 0.83
- ER Membrane Biogenesis · correlation 0.82
- Transcriptional Homeostasis · correlation 0.82
- mDC Vesicular Trafficking · correlation 0.79
- Lysosomal Vesicle Trafficking · correlation 0.75
- Chromatin Remodeling · correlation 0.75
- Actomyosin Cytoskeletal · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.