ER Protein Processing
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes converge on ER function: CRELD2 is a well-established UPR/ER stress marker; VCPIP1 participates in ERAD (ER-associated degradation) via VCP/p97; RPN1 is a core subunit of the oligosaccharyltransferase complex mediating N-glycosylation in the ER lumen; SFT2D2 is an ER-Golgi SNARE; FAR1 is ER-localized for ether lipid synthesis; DNAJC7 is an HSP40 co-chaperone supporting protein folding. ERAP2 trims peptides in the ER for MHC-I loading, linking this module to antigen processing. The overall program reflects ER protein processing and quality control, with a UPR/stress component. Moderate coherence with all genes at moderate/weak membership is consistent with a broad ER housekeeping program. Neighbor M107 shares ER chaperone DNAJC10 and vesicular trafficking, supporting an ER-to-Golgi neighborhood.
Genes
Most correlated modules
- Unfolded Protein Response · correlation 0.88
- Proliferating DC Housekeeping · correlation 0.80
- Cell Cycle Checkpoint · correlation 0.78
- ER Translocon Processing · correlation 0.77
- ER Protein Folding · correlation 0.77
- Lysosomal Vesicle Trafficking · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.