Metabolic Housekeeping
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 16 of 35 genes have a known function matching the annotation |
Why this annotation
Hub genes include ATP5MC3, ATP5PF, ATP5MF (ATP synthase subunits), NDUFA4, NDUFB3 (NADH dehydrogenase subunits), GAPDH, TPI1, TALDO1 (glycolysis/pentose phosphate), PSMA7, PSMB1, PSMB3 (proteasome subunits), CCT6A (chaperonin), RHOA (cytoskeletal GTPase), VPS29 (retromer), COPE (COPI vesicle coat), PPIA (cyclophilin A). Expression is uniform across subsets with high mean expression and pct positive, indicating a housekeeping program. Significantly upregulated in inflammation (delta_inflammation=0.650, sig.), suggesting metabolic/housekeeping upregulation during inflammatory activation. The mix of OxPhos, glycolysis, proteasome, and vesicle trafficking genes is characteristic of a general metabolic housekeeping module. Neighbor context: sits near M89 and M23 which are proliferation-associated; M14 is more broadly expressed (uniform) and represents the core metabolic housekeeping program shared across DC states.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.97
- Proteasome & Glycolysis · correlation 0.95
- Mitochondrial Ribosome Biogenesis · correlation 0.92
- Actin Polymerization · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.