Proteasome & Glycolysis
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 16 of 20 genes have a known function matching the annotation |
Why this annotation
The top hub genes are multiple proteasome subunits (PSMB9, PSMA3, PSMD8, PSMB8, PSMA5, PSMB6, PSMD14), glycolytic enzymes (ENO1, LDHA, PKM, PGAM1), translation initiation factors (EIF2S2, EIF5A), and mitochondrial complex IV subunits (COX6A1, COX7A2). PSMB9 and PSMB8 are immunoproteasome subunits induced by IFN-gamma, but the broader context here — with glycolytic enzymes, general proteasome subunits, and translation factors — suggests a general metabolic/proteostasis program rather than a dedicated immunoproteasome response. The strong upregulation with inflammation (delta_inflammation ~0.71 in both UC and CD) and enrichment in prolif_DC for LDHA, PSMD14, PGAM1 suggests this reflects a metabolically active, proliferating or activated DC state. UBL5 and UBE2L3 link to ubiquitin-proteasome pathway. The module is best described as proteasome-glycolysis coupling in activated/proliferating DCs. Neighbor M99 shares proteasome components (PSMA2, PSME1) and cytoskeletal/housekeeping genes, supporting a shared activated-DC metabolic neighborhood.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.95
- Oxidative Phosphorylation · correlation 0.91
- Actin Cytoskeleton Remodeling · correlation 0.83
- Inflammatory Stress Response · correlation 0.80
- Chromatin Remodeling · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.