Oxidative Phosphorylation
Gene co-expression module in Dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
This is a strong, coherent module with high mean expression (52% detection) and uniform expression across subsets. Hub genes are dominated by ATP synthase subunits (ATP5F1C, ATP5F1A, ATP5PO, ATP5PB, ATP5F1B — all core members of the F1Fo ATP synthase complex), COX5A (cytochrome c oxidase, complex IV), MDH1 (malate dehydrogenase, TCA cycle), PRDX3 (mitochondrial peroxiredoxin), MTCH2 (mitochondrial carrier), and GHITM (mitochondrial membrane protein). Additional genes include PSMB2/PSMD7 (proteasome), CCT7/CCT8 (chaperonin complex), HNRNPA1 (RNA binding), and CFL1 (actin dynamics). The oxidative phosphorylation signature is very strong and dominant. The module is significantly upregulated in inflammation (delta_inflammation 0.509, sig.), consistent with increased metabolic demand in activated DCs. This is a classic mitochondrial OxPhos module. Neighbor context: M112 and M118 share metabolic/mitochondrial genes, confirming a neighborhood of energy metabolism programs; M72 is the most coherent and OxPhos-specific of the group.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.97
- Mitochondrial Ribosome Biogenesis · correlation 0.92
- Mitochondrial Biogenesis · correlation 0.92
- Proteasome & Glycolysis · correlation 0.91
- DC Proliferation · correlation 0.91
- Mitochondrial OxPhos · correlation 0.89
- Proteostasis & Chaperones · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.