Mitochondrial Ribosome Biogenesis
Gene co-expression module in Dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include MRPL15, MRPL20 (mitochondrial ribosomal large subunit proteins), MRPS12, MRPS16 (mitochondrial ribosomal small subunit proteins), PPP4C (protein phosphatase 4, DNA repair/spliceosome), NUBP2 (iron-sulfur cluster assembly), IDH3G (TCA cycle), NDUFA12 (Complex I), HDGF (hepatoma-derived growth factor, nuclear/proliferation), LAGE3 (EKC/KEOPS complex, tRNA modification), POLR3GL (RNA Pol III), TSEN15 (tRNA splicing endonuclease), NUTF2 (nuclear transport), SSNA1 (centrosome/cilia). Module coherence is moderate with many moderate-membership genes. The dominant theme is mitochondrial ribosome biogenesis (MRPL15, MRPL20, MRPS12, MRPS16) combined with mitochondrial metabolism (NDUFA12, IDH3G, NUBP2). The tRNA processing genes (LAGE3, TSEN15, POLR3GL) and NUTF2 suggest a broader RNA/protein synthesis support program. Neighbor context: this module neighbors M89/M23 (proliferation) and M122 (mitochondrial), consistent with a mitochondrial translation/biogenesis program supporting proliferating DCs.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.92
- Oxidative Phosphorylation · correlation 0.92
- Mitochondrial Biogenesis · correlation 0.90
- Mitochondrial OxPhos · correlation 0.89
- Proteostasis & Chaperones · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.