Actin Polymerization
Gene co-expression module in Dendritic cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes ARPC3 and ARPC1B are core Arp2/3 complex subunits driving actin branch nucleation. BRK1 is a WAVE complex component that activates Arp2/3. CAP1 and CAPZA1 are actin capping proteins. MYL12A is a myosin regulatory light chain. TPM3 is tropomyosin. ARHGDIB (Rho GDI beta) regulates Rho GTPases upstream of actin. GNAI2 links GPCR signaling to cytoskeletal remodeling. CLTB (clathrin light chain) connects to endocytic actin dynamics. MTPN (myotrophin) promotes actin polymerization. The module is uniformly expressed across DC subsets with strong coherence, consistent with a constitutive cytoskeletal program rather than a cell-state-specific response. Neighbor M96 also contains ACTR2 (Arp2/3 subunit) and TLN1 (talin), reinforcing that this neighborhood captures cytoskeletal/adhesion programs.
Genes
Most correlated modules
- Oxidative Stress Response · correlation 0.90
- Endosomal Retromer Trafficking · correlation 0.88
- Metabolic Housekeeping · correlation 0.87
- Proteostasis & Chaperones · correlation 0.87
- G1/S Cell Cycle · correlation 0.85
- Type I Interferon · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.