Regulatory mDC Activation
Gene co-expression module in Dendritic cells
| Category | Tolerance |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes SLC7A11 (xCT, cystine/glutamate antiporter, oxidative stress defense), TNFRSF4 (OX40L, costimulatory ligand expressed on activated DCs), INHBA (activin A, TGF-beta superfamily cytokine), CXCL16 (chemokine/scavenger receptor), ALCAM (CD166, adhesion/migration), BCL2 (anti-apoptotic), ARID5B (transcription factor), STAT4 (IL-12 signaling TF), IRAK2 (IL-1R/TLR signaling), CALCRL (CGRP receptor), P2RX4 (purinergic receptor), and LGALS3 (galectin-3, pattern recognition). The strong mDC enrichment and combination of survival signals, cytokine production (INHBA/activin A), costimulation (TNFRSF4/OX40L), and oxidative stress defense (SLC7A11) suggest a tolerogenic or regulatory mDC activation state. STAT4 and IRAK2 indicate cytokine responsiveness. The module may represent mDCs responding to tissue damage signals with a mixed pro-survival/regulatory output.
Genes
Most correlated modules
- Tolerogenic mDC Activation · correlation 0.90
- mDC Tolerogenic Identity · correlation 0.84
- NF-κB DC Activation · correlation 0.83
- Lysosomal Antigen Processing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.