Epigenetic Regulation
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 20 genes have a known function matching the annotation |
Why this annotation
This strong-coherence module has uniform expression across subsets with mild mDC enrichment for some genes. Hub genes include KMT2A (MLL1, histone H3K4 methyltransferase, major epigenetic regulator), PRDM2 (histone methyltransferase), BAZ2A (chromatin remodeling, bromodomain), FOXO1 (transcription factor, DC differentiation/tolerance), SRPK2 (SR protein kinase, splicing regulation), ST3GAL6 (sialyltransferase, glycosylation), TIAM1 (Rac1 GEF, cytoskeletal/migration), CLCN7 (lysosomal chloride channel), and CREG1 (transcriptional regulator). The convergence of KMT2A, PRDM2, BAZ2A, and FOXO1 points to a chromatin remodeling/epigenetic regulation program. FOXO1 is known to regulate DC homeostasis and tolerance. The module shows no significant inflammation response. This appears to be a homeostatic epigenetic/transcriptional regulation program in mDC.
Genes
Most correlated modules
- Lysosomal Trafficking Regulation · correlation 0.89
- Chromatin Remodeling · correlation 0.88
- mTOR Nutrient Sensing · correlation 0.88
- Immature DC Metabolism · correlation 0.87
- CD1 Lipid Presentation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.