Chromatin Remodeling
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 29 genes have a known function matching the annotation |
Why this annotation
This strong-coherence module shows uniform expression across subsets with mild mDC enrichment. Hub genes include ARID4A and ARID1B (ARID-domain chromatin remodeling proteins, SWI/SNF complex), CELF2 (RNA-binding protein, splicing/mRNA regulation), SMG1 (PI3K-like kinase, nonsense-mediated decay), ASH1L (histone methyltransferase), CDYL (chromodomain, epigenetic reader), KDM5B (histone demethylase), PIAS1 (SUMO E3 ligase, transcriptional regulation), SOX4 (transcription factor, DC development), ANKRD11 (chromatin regulator). The convergence of ARID4A, ARID1B, ASH1L, CDYL, KDM5B, and PIAS1 strongly points to chromatin remodeling and epigenetic regulation. SOX4 is a known regulator of DC development. CELF2 and SMG1 add post-transcriptional regulation. This module likely represents a broad chromatin/epigenetic regulatory program active across DC subsets. Neighbor M27 also has epigenetic regulators, suggesting these two modules form a neighborhood of epigenetic programs.
Genes
Most correlated modules
- Lysosomal Trafficking Regulation · correlation 0.91
- Death Receptor Signaling · correlation 0.89
- mTOR Nutrient Sensing · correlation 0.88
- Epigenetic Regulation · correlation 0.88
- Non-canonical NF-κB · correlation 0.87
- mDC Inflammatory Activation · correlation 0.85
- Immature DC Metabolism · correlation 0.83
- CD1 Lipid Presentation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.