CD1 Lipid Presentation
Gene co-expression module in Dendritic cells
| Category | Ag processing & presentation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
The top hub genes CD1E and CD1B are CD1 family lipid antigen-presenting molecules expressed on mDCs, directly implicating lipid antigen presentation. CLCN5 (chloride channel involved in endosomal acidification, critical for lipid antigen loading), ENPP2 (autotaxin, generates lysophosphatidic acid), DAPK1 (death-associated protein kinase, regulates autophagy and antigen processing), WIPF1 (actin cytoskeleton remodeling at phagosomes), ARHGEF2 (Rho GEF, cytoskeletal regulation), RASGRP3 (Ras GRP, signaling downstream of antigen receptors), and PDLIM5 (cytoskeletal scaffold) support a program of lipid antigen processing and presentation via CD1 molecules. The moderate coherence reflects some mixing with cytoskeletal/signaling genes. As a neighbor to M87 (lysosomal antigen processing) and M117 (NF-κB activation), this module represents the specialized CD1-mediated lipid antigen presentation arm of mDC function.
Genes
Most correlated modules
- Lysosomal Trafficking Regulation · correlation 0.88
- Chromatin Remodeling · correlation 0.80
- IFNγ-primed Phagocytosis · correlation 0.80
- Epigenetic Regulation · correlation 0.78
- mDC Tolerogenic Identity · correlation 0.77
- NF-κB DC Activation · correlation 0.77
- Lysosomal Antigen Processing · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.