Lysosomal Trafficking Regulation
Gene co-expression module in Dendritic cells
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
This strong-coherence module is enriched in mDC. Key hub genes include UVRAG (autophagy regulator, BECN1 complex, also involved in endosomal maturation), LYST (Chediak-Higashi gene, lysosomal trafficking regulator), RUBCN (Rubicon, negative regulator of autophagy and LC3-associated phagocytosis), LRRK1 (kinase involved in endosomal/lysosomal trafficking), P2RY8 (purinergic receptor), DPP9 (intracellular peptidase, inflammasome regulation), TAOK3 (kinase), ARHGAP22 (Rho-GAP), and CCR6 (chemokine receptor for DC homing). UVRAG, LYST, RUBCN together strongly implicate lysosomal biogenesis and autophagy regulation. LYST is a master regulator of lysosomal trafficking. RUBCN negatively regulates LC3-associated phagocytosis. This module likely represents a lysosomal trafficking/autophagy regulatory program in mDC. Neighbor M134 is an inflammatory mDC module; M160 may represent the complementary vesicular/lysosomal arm of mDC biology.
Genes
Most correlated modules
- Death Receptor Signaling · correlation 0.92
- Chromatin Remodeling · correlation 0.91
- mDC Inflammatory Activation · correlation 0.91
- Non-canonical NF-κB · correlation 0.91
- Epigenetic Regulation · correlation 0.89
- CD1 Lipid Presentation · correlation 0.88
- Immature DC Metabolism · correlation 0.86
- DC Maturation Migration · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.